iFluor® 633 Anti-human CD8 Antibody *SK1*

SK1 is an anti-human monoclonal antibody that is specific for the CD8a antigen. CD8a (sometimes called MAL or Leu2) is a 32 - 34 kD member of the Ig superfamily that is expressed on the surface of cells such as NK cells and T cells. CD8 is a component of important cellular pathways, for example, the transmembrane receptor protein tyrosine kinase signaling pathway and cell surface receptor signaling pathway. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands like MHCI. CD8 is a very popular antibody target, with over 125000 publications in the last decade. CD8a is commonly used in flow cytometry applications as a phenotypic marker for differentiation of cell types, especially in the study of immunology. This antibody was purified through affinity chromatography and conjugated to iFluor® 633 (ex/em = 640/654 nm). It is compatible with the 640 nm laser and 660/10 nm bandpass filter (for example, as in the BD FACSMelody™).