iFluor® 670 Anti-human CD123 Antibody *12H7*

The 12H7 monoclonal antibody binds to human CD123, a 70 kD single-pass type I membrane protein often located on the surface of macrophages, hematopoietic progenitors and dendritic cells. CD123 acts in vital cellular pathways, for instance, the cytokine-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with essential macromolecules/ligands like CD131. CD123 is a fairly uncommon antibody target, with a little more than 3900 publications in the last decade. Even still, CD123 is essential for immunology research, typically serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to iFluor® 670 (ex/em = 671/682 nm). It is compatible with the 642 nm laser and 664/20 nm bandpass filter (for example, as in the Luminex Guava easyCyte).