iFluor® 750 RGD Conjugate
Ordering information
Price | |
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Physical properties
Molecular weight | ~1600 |
Solvent | DMSO |
Spectral properties
Correction Factor (260 nm) | 0.044 |
Correction Factor (280 nm) | 0.039 |
Correction Factor (565 nm) | 0.0250 |
Correction Factor (650 nm) | 0.1413 |
Extinction coefficient (cm -1 M -1) | 2750001 |
Excitation (nm) | 757 |
Emission (nm) | 779 |
Quantum yield | 0.121 |
Storage, safety and handling
H-phrase | H303, H313, H333 |
Hazard symbol | XN |
Intended use | Research Use Only (RUO) |
R-phrase | R20, R21, R22 |
Storage | Freeze (< -15 °C); Minimize light exposure |
UNSPSC | 12352200 |
Overview | ![]() ![]() |
See also: iFluor® Dyes and Kits
Molecular weight ~1600 | Correction Factor (260 nm) 0.044 | Correction Factor (280 nm) 0.039 | Correction Factor (565 nm) 0.0250 | Correction Factor (650 nm) 0.1413 | Extinction coefficient (cm -1 M -1) 2750001 | Excitation (nm) 757 | Emission (nm) 779 | Quantum yield 0.121 |
Near-infrared fluorescence optical imaging (also called in vivo Imaging) is emerging as a powerful technology for studying diseases at molecular level in small animal models. Water and biological tissues have minimal absorbance and autofluorescence in the NIR window (650-900 nm), thus allowing efficient photon penetration into, and out of tissue with low intra-tissue scattering. Across this NIR window, light absorption by physiologically abundant molecules such as hemoglobin, oxyhemoglobin and deoxyhemoglobin is also reduced to a minimum. In vivo imaging systems with biocompatible fluorescence agents are being developed and optimized for use in the near infrared spectral region - ensuring maximum light penetration and highest sensitivity. The cell adhesion molecule integrin is involved in angiogenesis and metastasis in many tumor types. Integrin is significantly up-regulated in activated endothelial cells and fast-growing solid tumor cells, compared to its minimum expression in quiescent blood vessels and most normal tissues. iFluor® 750-labeled monomeric arginine-glycine-aspartic acid (RGD) peptide c(RGDyK) specifically targets integrin both in cell culture and in living subjects. The in vivo efficacy of iFluor® 750-c(RGDyK) depends on many factors, including the receptor affinity, specificity, molecular size, overall molecular charge, hydrophilicity and metabolic stability.
Spectrum
Open in Advanced Spectrum Viewer


Spectral properties
Correction Factor (260 nm) | 0.044 |
Correction Factor (280 nm) | 0.039 |
Correction Factor (565 nm) | 0.0250 |
Correction Factor (650 nm) | 0.1413 |
Extinction coefficient (cm -1 M -1) | 2750001 |
Excitation (nm) | 757 |
Emission (nm) | 779 |
Quantum yield | 0.121 |
Product Family
Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) | Quantum yield | Correction Factor (260 nm) | Correction Factor (280 nm) | Correction Factor (565 nm) | Correction Factor (650 nm) |
iFluor® 750-streptavidin conjugate | 757 | 779 | 2750001 | 0.121 | 0.044 | 0.039 | 0.0250 | 0.1413 |
Phalloidin-iFluor® 750 Conjugate | 757 | 779 | 2750001 | 0.121 | 0.044 | 0.039 | 0.0250 | 0.1413 |
References
View all 31 references: Citation Explorer
Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization
Authors: P, undefined and ya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ.
Journal: Theranostics (2016): 698
Authors: P, undefined and ya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ.
Journal: Theranostics (2016): 698
c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma
Authors: Huang Y, Liu W, Gao F, Fang X, Chen Y.
Journal: Int J Nanomedicine (2016): 1629
Authors: Huang Y, Liu W, Gao F, Fang X, Chen Y.
Journal: Int J Nanomedicine (2016): 1629
99mTc-Glu-c(RGDyK)-Bombesin SPECT Can Reduce Unnecessary Biopsy of Masses That Are BI-RADS Category 4 on Ultrasonography
Authors: Ji T, Gao S, Liu Z, Xing H, Zhao G, Ma Q.
Journal: J Nucl Med (2016): 1196
Authors: Ji T, Gao S, Liu Z, Xing H, Zhao G, Ma Q.
Journal: J Nucl Med (2016): 1196
In Vivo Biodistribution and Anti-Tumor Efficacy Evaluation of Doxorubicin and Paclitaxel-Loaded Pluronic Micelles Decorated with c(RGDyK) Peptide
Authors: Chen Y, Zhang W, Huang Y, Gao F, Fang X.
Journal: PLoS One (2016): e0149952
Authors: Chen Y, Zhang W, Huang Y, Gao F, Fang X.
Journal: PLoS One (2016): e0149952
Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles
Authors: Gao Y, Zhou Y, Zhao L, Zhang C, Li Y, Li J, Li X, Liu Y.
Journal: Acta Biomater (2015): 127
Authors: Gao Y, Zhou Y, Zhao L, Zhang C, Li Y, Li J, Li X, Liu Y.
Journal: Acta Biomater (2015): 127
Dual-functional c(RGDyK)-decorated Pluronic micelles designed for antiangiogenesis and the treatment of drug-resistant tumor
Authors: Chen Y, Zhang W, Huang Y, Gao F, Fang X.
Journal: Int J Nanomedicine (2015): 4863
Authors: Chen Y, Zhang W, Huang Y, Gao F, Fang X.
Journal: Int J Nanomedicine (2015): 4863
The C(RgdyK)-conjugated Fe3O4 nanoparticles with high drug load for dual-targeting integrin alpha(v)beta3-expressing cancer cells
Authors: Guo L, Ding W, Zheng LM.
Journal: J Nanosci Nanotechnol (2014): 4858
Authors: Guo L, Ding W, Zheng LM.
Journal: J Nanosci Nanotechnol (2014): 4858
Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and (64)Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors
Authors: Oxboel J, Br and t-Larsen M, Schjoeth-Eskesen C, Myschetzky R, El-Ali HH, Madsen J, Kjaer A.
Journal: Nucl Med Biol (2014): 259
Authors: Oxboel J, Br and t-Larsen M, Schjoeth-Eskesen C, Myschetzky R, El-Ali HH, Madsen J, Kjaer A.
Journal: Nucl Med Biol (2014): 259
Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymer targeting tumor angiogenesis: tumor localization visualized by positron emission tomography
Authors: Yuan J, Zhang H, Kaur H, Oupicky D, Peng F.
Journal: Mol Imaging (2013): 203
Authors: Yuan J, Zhang H, Kaur H, Oupicky D, Peng F.
Journal: Mol Imaging (2013): 203
Design and biological evaluation of (9)(9)mTc-N(2)S(2)-Tat(49-57)-c(RGDyK): a hybrid radiopharmaceutical for tumors expressing alpha(v)beta(3) integrins
Authors: Ocampo-Garcia BE, Santos-Cuevas CL, De Leon-Rodriguez LM, Garcia-Becerra R, Ordaz-Rosado D, Luna-Guitierrez MA, Jimenez-Mancilla NP, Romero-Pina ME, Ferro-Flores G.
Journal: Nucl Med Biol (2013): 481
Authors: Ocampo-Garcia BE, Santos-Cuevas CL, De Leon-Rodriguez LM, Garcia-Becerra R, Ordaz-Rosado D, Luna-Guitierrez MA, Jimenez-Mancilla NP, Romero-Pina ME, Ferro-Flores G.
Journal: Nucl Med Biol (2013): 481
Application notes
A Meta-Analysis of Common Calcium Indicators
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
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