Name: iFluor® 750 RGD Conjugate
Brand: AAT Bioquest
SKU: 36800
Price: 348 USD
Availability: InStock

iFluor® 750 RGD Conjugate

Near-infrared fluorescence optical imaging (also called in vivo Imaging) is emerging as a powerful technology for studying diseases at molecular level in small animal models. Water and biological tissues have minimal absorbance and autofluorescence in the NIR window (650-900 nm), thus allowing efficient photon penetration into, and out of tissue with low intra-tissue scattering. Across this NIR window, light absorption by physiologically abundant molecules such as hemoglobin, oxyhemoglobin and deoxyhemoglobin is also reduced to a minimum. In vivo imaging systems with biocompatible fluorescence agents are being developed and optimized for use in the near infrared spectral region - ensuring maximum light penetration and highest sensitivity. The cell adhesion molecule integrin is involved in angiogenesis and metastasis in many tumor types. Integrin is significantly up-regulated in activated endothelial cells and fast-growing solid tumor cells, compared to its minimum expression in quiescent blood vessels and most normal tissues. iFluor® 750-labeled monomeric arginine-glycine-aspartic acid (RGD) peptide c(RGDyK) specifically targets integrin both in cell culture and in living subjects. The in vivo efficacy of iFluor® 750-c(RGDyK) depends on many factors, including the receptor affinity, specificity, molecular size, overall molecular charge, hydrophilicity and metabolic stability.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
36800	1 mg	Price

References

View all 31 references: Citation Explorer

Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization

Authors:

P, undefined and ya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ.

Journal:

Theranostics (2016): 698

c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma

Authors:

Huang Y, Liu W, Gao F, Fang X, Chen Y.

Journal:

Int J Nanomedicine (2016): 1629

99mTc-Glu-c(RGDyK)-Bombesin SPECT Can Reduce Unnecessary Biopsy of Masses That Are BI-RADS Category 4 on Ultrasonography

Authors:

Ji T, Gao S, Liu Z, Xing H, Zhao G, Ma Q.

Journal:

J Nucl Med (2016): 1196

In Vivo Biodistribution and Anti-Tumor Efficacy Evaluation of Doxorubicin and Paclitaxel-Loaded Pluronic Micelles Decorated with c(RGDyK) Peptide

Authors:

Chen Y, Zhang W, Huang Y, Gao F, Fang X.

Journal:

PLoS One (2016): e0149952

Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles

Authors:

Gao Y, Zhou Y, Zhao L, Zhang C, Li Y, Li J, Li X, Liu Y.

Journal:

Acta Biomater (2015): 127

Physical properties

Molecular weight	~1600
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.044
Correction factor (280 nm)	0.039
Correction factor (565 nm)	0.0250
Correction factor (650 nm)	0.1413
Extinction coefficient (cm ^-1 M ^-1)	275000 ¹
Excitation (nm)	757
Emission (nm)	779
Quantum yield	0.12 ¹

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on October 12, 2025