iFluor® 790 Anti-human/mouse CD44 Antibody *IM7*

IM7 is an anti-human/mouse monoclonal antibody that targets the CD44 antigen. CD44 (sometimes referred to as Epican, H-CAM, PGP-1 or ECMR III) is a 85 kD glycoprotein that is found on the surface of cells like NK cells, endothelial cells and macrophages. CD44 is involved with key cellular pathways, in particular, the negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and interferon-gamma-mediated signaling pathway. Moreover, in some organisms, it upregulates peptidyl-tyrosine phosphorylation, plays a role in the upregulation of ERK1 and ERK2 cascade and is a positive regulator of peptidyl-serine phosphorylation. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands like MIP1β, Ankyrin, Collagen and Osteopontin. CD44 is a very popular antibody target, with over 40000 publications in the last decade. CD44 is vital to cell adhesion, cell biology and immunology research, often serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to iFluor® 790 (ex/em = 787/812 nm).

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