Medetomidine biotin conjugate

Medetomidine biotin conjugate is a chemically modified derivative of medetomidine, an α2-adrenergic receptor agonist, functionalized with a biotin moiety to enable affinity-based detection and capture. This conjugate retains the high binding affinity and pharmacological specificity of native medetomidine toward α2-adrenergic receptors while incorporating a biotin tag for interaction with avidin- or streptavidin-based systems. The design preserves receptor-binding activity through a strategically positioned linker, minimizing steric hindrance and maintaining functional integrity of both the ligand and biotin. This reagent is particularly well-suited for applications such as receptor-ligand binding assays, target validation, affinity chromatography, and imaging studies, where precise receptor targeting and robust signal amplification are required. Medetomidine biotin conjugate is compatible with a range of in vitro and ex vivo experimental platforms and is an effective tool for dissecting adrenergic receptor function and pharmacodynamics in neurobiology and signal transduction research.

Page updated on June 29, 2025