Name: Medetomidine biotin conjugate
Brand: AAT Bioquest
SKU: 50654
Price: 989 USD
Availability: InStock

Medetomidine biotin conjugate

Medetomidine biotin conjugate is a biotinylated α2-adrenergic agonist that combines receptor binding with streptavidin affinity, enabling detection and purification of α2-adrenergic receptors and associated proteins.

Selective Binding: Retains high affinity and specificity for α2-adrenergic receptors
Biotin Functionalization: Enables detection and capture via streptavidin- or avidin-based systems
Preserved Pharmacological Activity: Designed to maintain native ligand–receptor interactions post-conjugation
Versatile Applications: Suitable for receptor binding assays, affinity purification, imaging, and target engagement studies
Experimental Compatibility: Effective in both in vitro and ex vivo systems across neuropharmacology and receptor signaling research

The chemical structure of Medetomidine biotin conjugate.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
50654	1 mg	Price

Overview

Medetomidine biotin conjugate is a chemically modified derivative of medetomidine, an α2-adrenergic receptor agonist, functionalized with a biotin moiety to enable affinity-based detection and capture. This conjugate retains the high binding affinity and pharmacological specificity of native medetomidine toward α2-adrenergic receptors while incorporating a biotin tag for interaction with avidin- or streptavidin-based systems. The design preserves receptor-binding activity through a strategically positioned linker, minimizing steric hindrance and maintaining functional integrity of both the ligand and biotin. This reagent is particularly well-suited for applications such as receptor-ligand binding assays, target validation, affinity chromatography, and imaging studies, where precise receptor targeting and robust signal amplification are required. Medetomidine biotin conjugate is compatible with a range of in vitro and ex vivo experimental platforms and is an effective tool for dissecting adrenergic receptor function and pharmacodynamics in neurobiology and signal transduction research.

References

View all 50 references: Citation Explorer

A RETROSPECTIVE STUDY COMPARING THE SAFETY OF KETAMINE-MEDETOMIDINE AND TILETAMINE-ZOLAZEPAM-MEDETOMIDINE FOR CHEMICAL RESTRAINT OF CAPTIVE PANTHERA SPP.

Authors:

Norman B, Alexander and Simpson-Brown, Elliott and Patterson B, Stuart

Journal:

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (2025): 16-24

Accidental coadministration of medetomidine, vatinoxan and ketamine in a cat.

Authors:

Koura, Maria and Koliou, Eleni and Kourmpeti, Stavroula and Kazakos, Georgios

Journal:

Veterinary anaesthesia and analgesia (2025)

Effects of hydromorphone alone and combined with medetomidine-vatinoxan or dexmedetomidine on alfaxalone induction dose and mean arterial pressure in dogs anesthetized with sevoflurane.

Authors:

Davis, Lily V and Hampton, Chiara E and Kleine, Stephanie A and Smith, Christopher K and Bussières, Genevieve and Zhu, Xiaojuan and Seddighi, Reza

Journal:

Veterinary anaesthesia and analgesia (2025): 43-52

Intranasal administration and intramuscular administration of medetomidine are effective for sedation and may increase cardiac size in cats.

Authors:

Kaya, Zehranur and Yanmaz, Latif Emrah

Journal:

Journal of the American Veterinary Medical Association (2025): 599-603

Comparison of intramuscular medetomidine versus medetomidine-vatinoxan sedation in bearded dragons (Pogonavitticeps).

Authors:

Pinho, Renata H and Reed, Maya and Chapman, Kelsey and Pang, Daniel Sj

Journal:

Veterinary anaesthesia and analgesia (2025): 72-77

Physical properties

Solvent

DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on April 14, 2026