mFluor™ UV375 Anti-human/ dog CD132 Antibody *TUGh4*

The TUGh4 monoclonal antibody binds to human/ dog CD132, a 64 - 70 kD member of the Ig superfamily frequently located on the surface of macrophages and B cells. CD132 is a component of important cellular pathways, namely, the interleukin-21-mediated signaling pathway, interleukin-9-mediated signaling pathway and interleukin-2-mediated signaling pathway. In addition, in certain organisms, it is an enhancer of phagocytosis. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as CD124, JAK1, CD25 and lck. CD132 is a relatively rare antibody target, with fewer than 800 publications in the last decade. Even still, CD132 has a variety of applications in immunology research, frequently serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to mFluor™ UV375 (ex/em = 351/387 nm). It is compatible with the 355 nm laser and 379/28 nm bandpass filter (for example, as in the BD LSRFortessa™ X-20).