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N6-Methyladenosine-Biotin conjugate

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Physical properties
Molecular weight753.87
SolventDMSO
Storage, safety and handling
H-phraseH303, H313, H340
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC41116134
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OverviewpdfSDSpdfProtocol


Molecular weight
753.87
N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA (snRNA) as well as several long non-coding RNA, such as Xist. The methylation of adenosine is directed by a large N6-Methyladenosine methyltransferase complex containing METTL3 as the SAM-binding sub-unit. The biological functions of m6A are mediated through a group of RNA binding proteins that specifically recognize the methylated adenosine on RNA. This biotinylated N6-Methyladenosine derivative can be used for detecting the RNA modifications related to N6-Methyladenosine.

Calculators


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of N6-Methyladenosine-Biotin conjugate to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM132.649 µL663.244 µL1.326 mL6.632 mL13.265 mL
5 mM26.53 µL132.649 µL265.298 µL1.326 mL2.653 mL
10 mM13.265 µL66.324 µL132.649 µL663.244 µL1.326 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

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Citations


View all 28 citations: Citation Explorer
HIV-1 envelope proteins up-regulate N (6)-methyladenosine levels of cellular RNA independently of viral replication
Authors: Tirumuru, N., Wu, L.
Journal: J Biol Chem (2019): 3249-3260
Changes of RNA N(6)-methyladenosine in the hormesis effect induced by arsenite on human keratinocyte cells
Authors: Chen, H., Zhao, T., Sun, D., Wu, M., Zhang, Z.
Journal: Toxicol In Vitro (2019): 84-92
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1alpha signalling axis
Authors: Zhuang, C., Zhuang, C., Luo, X., Huang, X., Yao, L., Li, J., Li, Y., Xiong, T., Ye, J., Zhang, F., Gui, Y.
Journal: J Cell Mol Med (2019): 2163-2173
A dynamic reversible RNA N(6) -methyladenosine modification: current status and perspectives
Authors: Bi, Z., Liu, Y., Zhao, Y., Yao, Y., Wu, R., Liu, Q., Wang, Y., Wang, X.
Journal: J Cell Physiol (2019): 7948-7956
Transcriptome-wide analysis of N6-methyladenosine uncovers its regulatory role in gene expression in the lepidopteran Bombyx mori
Authors: Li, B., Wang, X., Li, Z., Lu, C., Zhang, Q., Chang, L., Li, W., Cheng, T., Xia, Q., Zhao, P.
Journal: Insect Mol Biol (2019): se name="17100.enl" path="C:\Users\aatbi\Drop
RNA N6-methyladenosine modification participates in miR-660/E2F3 axis-mediated inhibition of cell proliferation in gastric cancer
Authors: He, X., Shu, Y.
Journal: Pathol Res Pract (2019): se name="17100.enl" path="C:\Users\aatbi\Drop
Importance of m N(6)-methyladenosine (m(6)A) RNA modification in cancer
Authors: Tuncel, G., Kalkan, R.
Journal: Med Oncol (2019): 36
The role of N(6)-methyladenosine RNA methylation in the heat stress response of sheep (Ovis aries)
Authors: Lu, Z., Ma, Y., Li, Q., Liu, E., Jin, M., Zhang, L., Wei, C.
Journal: Cell Stress Chaperones (2019): 333-342
Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats
Authors: Fu, Y., Zorman, B., Sumazin, P., Sanna, P. P., Repunte-Canonigo, V.
Journal: PLoS One (2019): e0203566
Identifying N(6)-methyladenosine sites using extreme gradient boosting system optimized by particle swarm optimizer
Authors: Zhao, X., Zhang, Y., Ning, Q., Zhang, H., Ji, J., Yin, M.
Journal: J Theor Biol (2019): 39-47