PacBlue Anti-human CD107 Antibody *H4B4*

H4B4 is an anti-human monoclonal antibody that targets the CD107b antigen. CD107b (sometimes called LAMP2 or LAMPb) is a 45 kD transmembrane protein that is found on the surface of cells like granulocytes and endothelial cells. In many organisms, CD107 is a suppressor of protein-containing complex assembly. Additionally, it has been associated with essential biological processes like chaperone-mediated autophagy, particularly protein targeting to lysosome involved in chaperone-mediated autophagy. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands. CD107 is a relatively rare antibody target, with fewer than 800 publications in the last decade. Even still, CD107b is typically used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of protein trafficking and clearance and neuroscience. This antibody was purified through affinity chromatography and conjugated to PacBlue (ex/em = 404/455 nm). It is compatible with the 405 nm laser and 450/50 nm bandpass filter (for example, as in the BD FACSCanto™ II).