PacOrange Anti-human CD64 Antibody *10.1*

The 10.1 monoclonal antibody binds with human CD64, a 72 kD single-pass type i membrane protein typically expressed on the surface of granulocytes, monocytes and dendritic cells. In some organisms, CD64 enhances protein tyrosine kinase activity. Moreover, it is a member of vital cellular pathways, for example, the interferon-gamma-mediated signaling pathway and Fc-gamma receptor signaling pathway involved in phagocytosis. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as . CD64 is a fairly uncommon antibody target, with a little more than 4000 publications in the last decade. Even still, CD64 is often used in flow cytometry applications as a phenotypic marker for differentiation of cell types, particularly in the study of immunology and innate immunity. This antibody was purified through affinity chromatography and conjugated to PacOrange (ex/em = 400/551 nm). It is compatible with the 405 nm laser and 537/65 nm bandpass filter (for example, as in the Luminex Amnis FlowSight).