PE/Cy5 Anti-human CD23 Antibody *EBVCS-5*

EBVCS-5 is an anti-human antibody that forms an immune complex with the CD23 antigen. CD23 (sometimes referred to as FcεRII, BLAST-2 or B6) is a glycoprotein that is expressed on the surface of cells like platelets, granulocytes, T cells, dendritic cells and epithelial cells. CD23 is a component of important cellular pathways, for example, the cytokine-mediated signaling pathway and Notch signaling pathway. Furthermore, in certain organisms, it is a promoter of nitric-oxide synthase activity, acts to positively regulate killing of cells of other organism and positively regulates nitric-oxide synthase biosynthetic process. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands like CD11b, CD21, IgE and CD11c. CD23 is a fairly uncommon antibody target, with a little more than 5800 publications in the last decade. Even still, CD23 is typically used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of . This antibody was purified through affinity chromatography and conjugated to PE/Cy5 (ex/em = 565/666 nm). It is compatible with the 561 nm laser and 670/30 nm bandpass filter (for example, as in the Bio-Rad ZE5 Cell Analyzer).

Page updated on September 17, 2024