PE Mouse Anti-human HLA-ABCE Antibody *TP25.99SF, monoclonal*

HLA class I histocompatibility antigen, α chain E is a transmembrane protein with a molecular weight of 46 kDa, expressed in the external side of plasma membrane, recycling endosome membrane and integral component of lumenal side of endoplasmic reticulum membrane of cells. In humans, HLA class I histocompatibility antigen, α chain E has been found to be involved in immune response and natural killer cell mediated immunity. It aids in organismal processes, for instance, antigen processing and presentation of peptide antigen via MHC class I, protection from natural killer cell mediated cytotoxicity and antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent. It is a suppressor of natural killer cell mediated cytotoxicity while also is a promoter of CD8-, α-beta T cell activation, interleukin-13 production and interleukin-4 production. It binds with T cell receptor, MHC class I protein and β-2-microglobulin. Additionally, sequencing of HLA class I histocompatibility antigen, α chain E has exemplified it contains 3 conserved structural units: cytoplasmic, extracellular and Ig-like C1-type domain. It is the subject of comprehensive study due to the fact that it is involved with the interferon-γ-mediated signaling pathway and type I interferon signaling pathway.