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Psoralen TMP Succinimidyl Ester
Ordering information
| Price | |
| Catalog Number | |
| Unit Size | |
| Quantity |
Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 468.45 |
| Solvent | DMSO |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
Alternative formats
| Psoralen TMP Maleimide |
| Psoralen TMP Azide |
| Psoralen TMP Alkyne |
| Overview |  SDSProtocol |
Molecular weight 468.45 |
Psoralens and their derivatives (such as 8-TMP and 4,5’,8-TMP) are well known to have unique crosslinking features to DNA. Psoralen TMP Succinimidyl Ester is an amino-reactive TMP derivative. It is an excellent building block for preparing TMP-labeled oligos from the readily available amino-modified oligos. The TMP-conjugated oligonucleotides can be used for sequence-specific crosslinking with a target DNA, thus enabling the application of psoralen-conjugated molecules in gene transcription inhibition, gene knockout, and other genomic applications. Psoralen TMP Succinimidyl Ester may also be used for preparing site-specific DNA/RNA probes via the conjugations with amino-containing biomolecules such as antibodies.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Psoralen TMP Succinimidyl Ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 213.47 µL | 1.067 mL | 2.135 mL | 10.673 mL | 21.347 mL |
| 5 mM | 42.694 µL | 213.47 µL | 426.94 µL | 2.135 mL | 4.269 mL |
| 10 mM | 21.347 µL | 106.735 µL | 213.47 µL | 1.067 mL | 2.135 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Images
Figure 1. Psoralen TMP Succinimidyl Ester is an amino-reactive TMP derivative. It is an excellent building block for preparing TMP-labeled oligos from the readily available amino-modified oligos.
References
View all 50 references: Citation Explorer
Tracing the Photoaddition of Pharmaceutical Psoralens to DNA.
Authors: Diekmann, Janina and Theves, Isabell and Thom, Kristoffer A and Gilch, Peter
Journal: Molecules (Basel, Switzerland) (2020)
Authors: Diekmann, Janina and Theves, Isabell and Thom, Kristoffer A and Gilch, Peter
Journal: Molecules (Basel, Switzerland) (2020)
Nucleotide Excision Repair, XPA-1, and the Translesion Synthesis Complex, POLZ-1 and REV-1, Are Critical for Interstrand Cross-Link Repair in Caenorhabditis elegans Germ Cells.
Authors: Oh, Sinae and Bae, Woori and Alfhili, Mohammad A and Lee, Myon Hee
Journal: Biochemistry (2020): 3554-3561
Authors: Oh, Sinae and Bae, Woori and Alfhili, Mohammad A and Lee, Myon Hee
Journal: Biochemistry (2020): 3554-3561
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.
Authors: Wilson, David M and Rieckher, Matthias and Williams, Ashley B and Schumacher, Björn
Journal: Nucleic acids research (2017): 9467-9480
Authors: Wilson, David M and Rieckher, Matthias and Williams, Ashley B and Schumacher, Björn
Journal: Nucleic acids research (2017): 9467-9480
Modulation of the UVB-induced lethality by furocoumarins in Staphylococcus aureus.
Authors: Silva, Emanuelle B F and Barbosa, Ideltônio J F and Barreto, Humberto M and Siqueira-Júnior, José P
Journal: Journal of photochemistry and photobiology. B, Biology (2014): 260-3
Authors: Silva, Emanuelle B F and Barbosa, Ideltônio J F and Barreto, Humberto M and Siqueira-Júnior, José P
Journal: Journal of photochemistry and photobiology. B, Biology (2014): 260-3
Methods for single/low-copy integration by ultraviolet and trimethylpsoralen treatment in Caenorhabditis elegans.
Authors: Kage-Nakadai, Eriko and Imae, Rieko and Yoshina, Sawako and Mitani, Shohei
Journal: Methods (San Diego, Calif.) (2014): 397-402
Authors: Kage-Nakadai, Eriko and Imae, Rieko and Yoshina, Sawako and Mitani, Shohei
Journal: Methods (San Diego, Calif.) (2014): 397-402
Single/low-copy integration of transgenes in Caenorhabditis elegans using an ultraviolet trimethylpsoralen method.
Authors: Kage-Nakadai, Eriko and Kobuna, Hiroyuki and Funatsu, Osamu and Otori, Muneyoshi and Gengyo-Ando, Keiko and Yoshina, Sawako and Hori, Sayaka and Mitani, Shohei
Journal: BMC biotechnology (2012): 1
Authors: Kage-Nakadai, Eriko and Kobuna, Hiroyuki and Funatsu, Osamu and Otori, Muneyoshi and Gengyo-Ando, Keiko and Yoshina, Sawako and Hori, Sayaka and Mitani, Shohei
Journal: BMC biotechnology (2012): 1
An introduction to worm lab: from culturing worms to mutagenesis.
Authors: Chaudhuri, Jyotiska and Parihar, Manish and Pires-daSilva, Andre
Journal: Journal of visualized experiments : JoVE (2011)
Authors: Chaudhuri, Jyotiska and Parihar, Manish and Pires-daSilva, Andre
Journal: Journal of visualized experiments : JoVE (2011)
Whole-genome profiling of mutagenesis in Caenorhabditis elegans.
Authors: Flibotte, Stephane and Edgley, Mark L and Chaudhry, Iasha and Taylor, Jon and Neil, Sarah E and Rogula, Aleksandra and Zapf, Rick and Hirst, Martin and Butterfield, Yaron and Jones, Steven J and Marra, Marco A and Barstead, Robert J and Moerman, Donald G
Journal: Genetics (2010): 431-41
Authors: Flibotte, Stephane and Edgley, Mark L and Chaudhry, Iasha and Taylor, Jon and Neil, Sarah E and Rogula, Aleksandra and Zapf, Rick and Hirst, Martin and Butterfield, Yaron and Jones, Steven J and Marra, Marco A and Barstead, Robert J and Moerman, Donald G
Journal: Genetics (2010): 431-41
Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC).
Authors: Fang, Jia-You and Fang, Chia-Lang and Liu, Chi-Hsien and Su, Yu-Han
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenst (2008): 633-40
Authors: Fang, Jia-You and Fang, Chia-Lang and Liu, Chi-Hsien and Su, Yu-Han
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenst (2008): 633-40
Comparison of systemic PUVA and NB-UVB in the treatment of vitiligo: an open prospective study.
Authors: Bhatnagar, A and Kanwar, A J and Parsad, D and De, D
Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (2007): 638-42
Authors: Bhatnagar, A and Kanwar, A J and Parsad, D and De, D
Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (2007): 638-42