Purified Anti-human CD11a Antibody *TS-1/22.1.1.13*

TS-1/22.1.1.13 is an anti-human monoclonal antibody that targets the CD11a antigen. CD11a (also known as ITGAL or LFA-1α chain) is a 170 - 180 kD transmembrane glycoprotein that is found on the surface of cells such as NK cells, T cells, macrophages and B cells. CD11a plays a role in vital cellular pathways, namely, the integrin-mediated signaling pathway. Also, it has been closely linked to key biological processes like cell-cell adhesion, especially leukocyte cell-cell adhesion. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands like ICAM-1 and CD18. CD11a is a fairly uncommon antibody target, with a little more than 3000 publications in the last decade. Even still, CD11a is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of costimulatory molecules, neuroinflammation and innate immunity. This antibody was purified through affinity chromatography.

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