Purified Anti-human CD24 Antibody *HI45*

HI45 is an anti-human monoclonal antibody that is specific for the CD24 antigen. CD24 (also known as Nectadrin or Ly-52) is a 35 - 45 kD transmembrane protein that is expressed on the surface of cells such as granulocytes, B cells and epithelial cells. CD24 acts in important cellular pathways, for instance, the immune response-regulating cell surface receptor signaling pathway, Wnt signaling pathway and intrinsic apoptotic signaling pathway. Also, in some organisms, it is involved in the negative regulation of transforming growth factor beta3 production, plays a role in the upregulation of activated T cell proliferation and is involved in the positive regulation of MAP kinase activity. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands like CD62P (P-Selectin). CD24 is a moderately popular antibody target, with over 12000 publications in the last decade. CD24 has a variety of applications in cell biology and immunology research, commonly serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography.