Purified Anti-human CD38 Antibody *HIT2*

HIT2 is an anti-human monoclonal antibody that targets the CD38 antigen. CD38 (alternatively called T10) is a 45 kD transmembrane protein that is found on the surface of cells such as NK cells, macrophages and stem cells. CD38 is a component of vital cellular pathways, namely, the apoptotic signaling pathway and B cell receptor signaling pathway. In addition, in certain organisms, it represses apoptotic process, is a positive regulator of cell growth and is an enhancer of vasoconstriction. From a research standpoint, it is of biological interest due to its association with critical macromolecules/ligands like HLA Class II, CD31, CD16 and Hyaluronic acid. CD38 is a fairly uncommon antibody target, with a little more than 10000 publications in the last decade. Even still, CD38 has been widely used in immunology research, commonly serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography.