Clusterin is a 61 kDa protein that can be found in the nucleus, protein-containing complex and intracellular membrane-bounded organelle of cells. It is sometimes referred to as Apolipoprotein J, complement cytolysis inhibitor, sulfated glycoprotein 2 and complement-associated protein SP-40,40. In humans, clusterin is the subject of intensive research in part because of the fact that it plays a role in the complement activation, classical pathway, positive regulation of intrinsic apoptotic signaling pathway and intrinsic apoptotic signaling pathway. Clusterin plays an important role in organismal processes, namely, microglial cell activation, antimicrobial humoral response and response to misfolded protein. It positively regulates apoptotic process, NF-kappaB transcription factor activity and protein-containing complex assembly. On the other hand, it also suppresses protein-containing complex assembly, release of cytochrome c from mitochondria and amyloid fibril formation. Clusterin binds to unfolded protein, protein-containing complex and ubiquitin protein ligase. It has been associated with vital functions like protein heterodimerization activity. Additionally, clusterin has been found to be involved in apoptotic process, neuronal signal transduction and neuron death.
We provide custom conjugation services for this antibody (e.g. labeling of Clusterin antibody with HRP). A list of available labels can be found in the table below: