Purified Mouse Anti-human H-RAS Antibody *H-RAS-03, monoclonal*

GTPase HRas is a 21 kDa protein that can be found in the perinuclear region of cytoplasm, plasma membrane and nucleoplasm of cells. It is sometimes referred to as H-Ras-1, p21ras and Transforming protein p21. In humans, GTPase HRas is an inhibitor of gene expression, cell population proliferation and neuron apoptotic process on the other hand also upregulates ras protein signal transduction, epithelial cell proliferation and actin cytoskeleton reorganization. GTPase HRas aids in organismal processes, namely, cellular senescence, defense response to protozoan and response to isolation stress. It binds with S-farnesyl cysteine, GDP and protein C-terminus. It has been closely linked to essential functions such as GTPase activity. GTPase HRas is the subject of extensive study due to the fact that it is a component of the T cell receptor signaling pathway, stimulatory C-type lectin receptor signaling pathway and ephrin receptor signaling pathway. GTPase HRas aids in neurotransmitter receptor localization to postsynaptic specialization membrane and long-term neuronal synaptic plasticity. Mutations and abnormalities in GTPase HRas have been associated with a number of diseases, for instance, Schimmelpenning-Feuerstein-Mims syndrome (SFM), nonmedullary thyroid cancer (NMTC) and Costello syndrome. Costello syndrome, a disorder characterized by ;ow-set ears, developmental delay and pectus carinatum, has in specific been of interest to researchers.