Name: Purified Mouse Anti-human HLA-DR Antibody *HL-39, monoclonal*
Brand: AAT Bioquest
SKU: V103915
Price: 373 USD
Availability: InStock

Purified Mouse Anti-human HLA-DR Antibody

HL-39, monoclonal

HLA class II histocompatibility antigen γ chain (sometimes referred to as Ia antigen-associated invariant chain, HLA-DR antigens-associated invariant chain, Ii or p33) is a transmembrane protein with a molecular weight of 39 kDa, found in the trans-Golgi network membrane, integral component of membrane and nucleus of cells. Sequencing of HLA class II histocompatibility antigen γ chain has exemplified it contains 3 conserved structural units: cytoplasmic, thyroglobulin type-1 and extracellular domain. p33 is thought to be essential to macrophage activation. It recognizes CD4 receptor, identical protein and MHC class II protein complex. It aids in organismal processes, for example, cell population proliferation, chaperone cofactor-dependent protein refolding and negative thymic T cell selection. HLA class II histocompatibility antigen γ chain positively regulates fibroblast proliferation, kinase activity and MAPK cascade. And it also is involved in the negative regulation of T cell differentiation, mature B cell apoptotic process and apoptotic process. HLA class II histocompatibility antigen γ chain is the subject of extensive application in part because of the fact that it is a component of the positive regulation of cytokine-mediated signaling pathway, positive regulation of macrophage migration inhibitory factor signaling pathway and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, and furthermore, has been thought to be involved with critical functions such as cytokine receptor activity.

General packaging for catalog V103915. Actual shipped packaging may vary.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
V103915	0.1 mg	Price

Conjugation

We provide custom conjugation services for this antibody (e.g. labeling of HLA-DR antibody with HRP). A list of available labels can be found in the table below:

Label Type	Available Labels
AF	AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750
Proteins	HRP, Alkaline Phosphatase, Streptavidin
Tandems	APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5
Small Molecules	Biotin
Traditional Dyes	FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5
iFluor	350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7
mFluor	UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780

For additional information about custom conjugations, please consult our services page

here

Antibody properties

Clone	HL-39
Host	mouse
Reactivity	human
Application	FC (QC TESTED); IP

Storage, safety and handling

Intended use

Research Use Only (RUO)

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Fax
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Bulk request	Inquire
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Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on September 21, 2025