Purified Mouse Anti-human HLA-DR Antibody *MEM-12, monoclonal*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | SDSProtocol |
See also: Antibodies and Proteomics, Immunoprecipitation
Other names | Clone MEM-12 | Host mouse | Reactivity human | Application FC (QC TESTED); IP; WB |
HLA class II histocompatibility antigen γ chain (sometimes referred to as Ia antigen-associated invariant chain, HLA-DR antigens-associated invariant chain, Ii or p33) is a transmembrane protein with a molecular weight of 39 kDa, found in the trans-Golgi network membrane, integral component of membrane and nucleus of cells. Sequencing of HLA class II histocompatibility antigen γ chain has exemplified it contains 3 conserved structural units: cytoplasmic, thyroglobulin type-1 and extracellular domain. p33 is thought to be essential to macrophage activation. It recognizes CD4 receptor, identical protein and MHC class II protein complex. It aids in organismal processes, for example, cell population proliferation, chaperone cofactor-dependent protein refolding and negative thymic T cell selection. HLA class II histocompatibility antigen γ chain positively regulates fibroblast proliferation, kinase activity and MAPK cascade. And it also is involved in the negative regulation of T cell differentiation, mature B cell apoptotic process and apoptotic process. HLA class II histocompatibility antigen γ chain is the subject of extensive application in part because of the fact that it is a component of the positive regulation of cytokine-mediated signaling pathway, positive regulation of macrophage migration inhibitory factor signaling pathway and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, and furthermore, has been thought to be involved with critical functions such as cytokine receptor activity.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of HLA-DR antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
FAQ
How can I lyse my cells without lysing the nuclear membrane?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?