Purified Mouse Anti-human LCK Antibody *LCK-01, monoclonal, Cross Adsorbed*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics, Immunoprecipitation
Other names | Clone LCK-01 | Host mouse | Reactivity human | Application FC; IP; WB; ICC |
Tyrosine-protein kinase Lck is a 58 kDa protein that can be located in the pericentriolar material, extracellular exosome and cytosol of cells. It is alternatively called Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16 and T cell-specific protein-tyrosine kinase. In Homo sapiens, tyrosine-protein kinase Lck has been thought to be involved with key functions such as protein tyrosine kinase, protein serine/threonine phosphatase and non-membrane spanning protein tyrosine kinase activity. It is an integral part of lymphocyte activation, cell population proliferation and defense response to virus. Tyrosine-protein kinase Lck is the subject of intensive examination in part because of the fact that it is a component of the positive regulation of T cell receptor signaling pathway, T cell receptor signaling pathway and positive regulation of intrinsic apoptotic signaling pathway. It is involved in the positive regulation of T cell activation, protein kinase B signaling and leukocyte cell-cell adhesion, and in addition, plays an important role in organismal processes, namely, cell differentiation, protein phosphorylation and T cell costimulation. Sequencing of tyrosine-protein kinase Lck has exemplified it contains 3 types of conserved structural units: protein kinase, SH2 and SH3 domain. Tyrosine-protein kinase Lck reacts with ATP, T cell receptor and protein phosphatase. Mutations and abnormalities in tyrosine-protein kinase Lck have been associated with a number of diseases, for example, immunodeficiency 22 (IMD22). Immunodeficiency 22, an autosomal recessive inheritancedisorder characterized by failure to thrive, autoimmunity and immunodeficiency, has in specific been of interest to scientists.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of LCK antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
FAQ
How can I lyse my cells without lysing the nuclear membrane?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?