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Purified Mouse Anti-human LCK Antibody
LCK-01, monoclonal, Cross Adsorbed
Tyrosine-protein kinase Lck is a 58 kDa protein that can be located in the pericentriolar material, extracellular exosome and cytosol of cells. It is alternatively called Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16 and T cell-specific protein-tyrosine kinase. In Homo sapiens, tyrosine-protein kinase Lck has been thought to be involved with key functions such as protein tyrosine kinase, protein serine/threonine phosphatase and non-membrane spanning protein tyrosine kinase activity. It is an integral part of lymphocyte activation, cell population proliferation and defense response to virus. Tyrosine-protein kinase Lck is the subject of intensive examination in part because of the fact that it is a component of the positive regulation of T cell receptor signaling pathway, T cell receptor signaling pathway and positive regulation of intrinsic apoptotic signaling pathway. It is involved in the positive regulation of T cell activation, protein kinase B signaling and leukocyte cell-cell adhesion, and in addition, plays an important role in organismal processes, namely, cell differentiation, protein phosphorylation and T cell costimulation. Sequencing of tyrosine-protein kinase Lck has exemplified it contains 3 types of conserved structural units: protein kinase, SH2 and SH3 domain. Tyrosine-protein kinase Lck reacts with ATP, T cell receptor and protein phosphatase. Mutations and abnormalities in tyrosine-protein kinase Lck have been associated with a number of diseases, for example, immunodeficiency 22 (IMD22). Immunodeficiency 22, an autosomal recessive inheritancedisorder characterized by failure to thrive, autoimmunity and immunodeficiency, has in specific been of interest to scientists.
| Catalog | Size | Price | Quantity |
|---|---|---|---|
| V1031650 | 0.1 mg | Price |
Antibody properties
| Clone | LCK-01 |
| Host | Mouse |
| Reactivity | Human |
| Application | Flow Cytometry (FACS), IP, Western Blot, ICC |
Storage, safety and handling
| Intended use | Research Use Only (RUO) |
Contact us
| Telephone | |
| Fax | |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Technical Support | Contact us |
| Request quotation | Request |
| Purchase order | Send to sales@aatbio.com |
| Shipping | Standard overnight for United States, inquire for international |
Page updated on June 13, 2026