Purified Mouse Anti-human/mouse FYN Antibody *FYN-01, monoclonal*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics, Immunoprecipitation
Other names | Clone FYN-01 | Host mouse | Reactivity human; mouse | Application IP; WB; IHC(P); ICC |
Tyrosine-protein kinase Fyn (also known as Src-like kinase, Proto-oncogene c-Fyn, SLK, Proto-oncogene Syn or p59-Fyn) is a protein with a molecular weight of 61 kDa, found in the perinuclear endoplasmic reticulum, cytosol and glutamatergic synapse of cells. In humans, tyrosine-protein kinase Fyn aids in cell shape, defense response to virus and calcium ion import across plasma membrane. It binds with identical protein, τ protein and ephrin receptor. Tyrosine-protein kinase Fyn aids in organismal processes, in particular, axon guidance, response to amyloid-β and neuron migration. Sequencing of tyrosine-protein kinase Fyn has supported it contains 3 conserved structural units: SH2, SH3 and protein kinase domain. It has been found to be involved in calcium ion import across plasma membrane, peptidyl-tyrosine phosphorylation and cell population proliferation. Tyrosine-protein kinase Fyn is a suppressor of protein catabolic process, protein ubiquitination and dendritic spine maintenance. On the other hand, it also promotes protein targeting to membrane, neuron projection development and non-membrane spanning protein tyrosine kinase activity. Tyrosine-protein kinase Fyn is the subject of intensive examination in part because of the fact that it acts in the vascular endothelial growth factor receptor signaling pathway, ephrin receptor signaling pathway and Fc-γ receptor signaling pathway involved in phagocytosis.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of FYN antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A Meta-Analysis of Common Calcium Indicators
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
FAQ
Are Cell Navigator® Cell Plasma Membrane Staining Kits suitable for cell culture medium samples?
Are there any alternatives to BrdU (Bromodeoxyuridine)?
Are there any alternatives to Cy5?
Are there any alternatives to indocyanine green (ICG)?
Are there any calcium indicators that don't require probenecid (PBC)?
Are there any alternatives to BrdU (Bromodeoxyuridine)?
Are there any alternatives to Cy5?
Are there any alternatives to indocyanine green (ICG)?
Are there any calcium indicators that don't require probenecid (PBC)?