Purified Mouse Anti-human/mouse/hamster β-Catenin Antibody *EM-22, monoclonal*

Catenin β-1 is a 100 kDa protein that can be located in the cytoplasm, microvillus membrane and plasma membrane of cells. In humans, catenin β-1 has been found to be involved in organismal processes, namely, sympathetic ganglion development, osteoclast differentiation and embryonic hindlimb morphogenesis. Catenin β-1 binds to nuclear hormone receptor, protein C-terminus and SMAD. It is the subject of intensive study stemming from the fact that it is a member of the canonical Wnt signaling pathway and negative regulation of apoptotic signaling pathway. Catenin β-1 is thought to be essential to calcium ion import, myelination and secondary heart field cardioblast proliferation. It negatively regulates cell population proliferation, mitotic cell cycle, embryonic and protein sumoylation and it also plays a role in the upregulation of apoptotic process, telomere maintenance via telomerase and histone H3-K4 methylation. Catenin β-1 has been thought to be involved with essential functions such as DNA-binding transcription factor and transcription coactivator activity. Mutations and abnormalities in Catenin β-1 have been thought to be involved with a number of diseases, in particular, colorectal cancer (CRC), vitreoretinopathy, exudative 7 (EVR7) and ovarian cancer (OC). Neurodevelopmental disorder with spastic diplegia and visual defects, an autosomal dominant inheritancedisorder characterized by global developmental delay, exudative vitreoretinopathy and generalized hypopigmentation, has especially been of interest to investigators.