Purified Mouse Anti-human/mouse Notch1 Antibody *mN1A, monoclonal, Cross Adsorbed*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics, Immunoprecipitation
Other names | Clone mN1A | Host mouse | Reactivity human; mouse | Application FC (QC TESTED); IP; WB; IHC(F); ICC |
Neurogenic locus notch homolog protein 1 (Notch 1) is a 273 kDa transmembrane protein that can be expressed in the integral component of membrane, acrosomal vesicle and apical plasma membrane of cells. In Homo sapiens, eurogenic locus notch homolog protein 1 is the subject of extensive study in part because of the fact that it is a component of the negative regulation of BMP signaling pathway, Notch signaling pathway and positive regulation of BMP signaling pathway. Neurogenic locus notch homolog protein 1 is an integral part of organismal processes, namely, endoderm development, ventricular trabecula myocardium morphogenesis and cellular response to vascular endothelial growth factor stimulus. It takes part in processes such as somitogenesis and DNA-templated transcription. Neurogenic locus notch homolog protein 1 has been thought to be involved with key functions like enzyme inhibitor and transmembrane signaling receptor activity. It negatively regulates pro-B cell differentiation, ossification and cell population proliferation, conversely, also acts to positively regulate cardiac epithelial to mesenchymal transition, transcription from RNA polymerase II promoter in response to hypoxia and cell population proliferation. Neurogenic locus notch homolog protein 1 is clinically significant because abnormalities in its function have been closely linked to diseases such as Aortic valve disease 1 (AOVD1) and Adams-Oliver syndrome 5 (AOS5). Adams-Oliver syndrome 5, an autosomal dominant inheritancedisorder characterized by right atrial enlargement, congenital livedo reticularis and hypersplenism, has especially been of interest to researchers.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of Notch1 antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A Meta-Analysis of Common Calcium Indicators
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
FAQ
Are Cell Navigator® Cell Plasma Membrane Staining Kits suitable for cell culture medium samples?
Are there any alternatives to BrdU (Bromodeoxyuridine)?
Are there any alternatives to Cy5?
Are there any alternatives to indocyanine green (ICG)?
Are there any calcium indicators that don't require probenecid (PBC)?
Are there any alternatives to BrdU (Bromodeoxyuridine)?
Are there any alternatives to Cy5?
Are there any alternatives to indocyanine green (ICG)?
Are there any calcium indicators that don't require probenecid (PBC)?