Purified Mouse Anti-human/mouse/rabbit Acidic Cytokeratins Antibody *AE1, monoclonal*

Keratin, type I cytoskeletal 10 (sometimes referred to as Cytokeratin-10, K10, CK-10 or Keratin-10) is a protein with a molecular weight of 69 kDa, located in the cornified envelope, nucleus and cytoplasm of cells. In humans, Keratin-10 has been closely linked to vital functions like protein heterodimerization activity. Sequencing of keratin-10 has shown it contains a primary structural unit, the IF rod domain. Keratin-10 promotes epidermis development. It is thought to be essential to organismal processes, namely, protein heterotetramerization, cornification and keratinocyte differentiation. Mutations and abnormalities in Keratin-10 have been associated with a number of diseases, for instance, epidermolytic hyperkeratosis (EHK), annular epidermolytic ichthyosis (AEI) and erythroderma, ichthyosiform, congenital reticular (CRIE). Epidermolytic hyperkeratosis, a disorder characterized by erythroderma, abnormal blistering of the skin and scaling skin, has especially been of interest to researchers.