Purified Mouse Anti-human/mouse STAT1 Antibody *SM1, monoclonal*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics, Immunoprecipitation
Other names | Clone SM1 | Host mouse | Reactivity human; mouse | Application IP; WB; IHC(P) |
Signal transducer and activator of transcription 1-alpha/beta is a protein with a molecular weight of 87 kDa, found in the dendrite, perinuclear region of cytoplasm and nucleoplasm of cells. Sequencing of signal transducer and activator of transcription 1-alpha/beta has shown it contains a primary structural unit, the SH2 domain. Signal transducer and activator of transcription 1-alpha/beta plays an important role in DNA-templated transcription, apoptotic process and cell population proliferation. It takes part in organismal processes, in particular, response to peptide hormone, response to cytokine and viral process. Signal transducer and activator of transcription 1-alpha/beta has been thought to be involved with vital functions like protein homodimerization and DNA-binding transcription factor activity. It is the subject of extensive study because of the fact that it acts in the receptor signaling pathway via JAK-STAT, interleukin-9-mediated signaling pathway and tumor necrosis factor-mediated signaling pathway. Signal transducer and activator of transcription 1-alpha/beta upregulates transcription of Notch receptor target, mesenchymal cell proliferation and interferon-α production, conversely, also represses metanephric nephron tubule epithelial cell differentiation, mesenchymal to epithelial transition involved in metanephros morphogenesis and I-kappaB kinase/NF-kappaB signaling. Mutations and abnormalities in signal transducer and activator of transcription 1-alpha/beta have been closely linked to a number of diseases, for instance, immunodeficiency 31A (IMD31A), immunodeficiency 31B (IMD31B) and immunodeficiency 31C (IMD31C). Immunodeficiency 31C, an autosomal dominant inheritancedisorder characterized by immunodeficiency, diabetes mellitus and osteopenia, has especially been of interest to researchers.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of STAT1 antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
FAQ
How can I lyse my cells without lysing the nuclear membrane?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?