Purified Mouse Anti-human/non-human primates p53 Antibody *BP53-12, monoclonal*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics, Immunoprecipitation
Other names | Clone BP53-12 | Host mouse | Reactivity human; non-human primates | Application FC (QC TESTED); IP; WB; IHC(P); ICC; ELISA |
Cellular tumor antigen p53 is a 44 kDa protein that can be located in the nucleus, mitochondrial matrix and centrosome of cells. It is sometimes referred to as Tumor suppressor p53, Phosphoprotein p53 and Antigen NY-CO-13. In Homo sapiens, cellular tumor antigen p53 has been closely linked to important functions like protein heterodimerization, DNA-binding transcription factor and histone deacetylase regulator activity. Cellular tumor antigen p53 is the subject of intensive examination stemming from the fact that it is involved with regulation of intrinsic apoptotic signaling pathway by p53 class mediator and intrinsic apoptotic signaling pathway in response to hypoxia. Cellular tumor antigen p53 aids in organismal processes, for instance, bone marrow development, cellular response to DNA damage stimulus and signal transduction by p53 class mediator, and moreover, aids in mitochondrial membrane permeability involved in apoptotic process, cell cycle G2/M phase transition and signal transduction by p53 class mediator. Cellular tumor antigen p53 downregulates transcription by RNA polymerase II and DNA-templated transcription, but also is an enhancer of pri-miRNA transcription by RNA polymerase II, cell aging and cardiac muscle cell apoptotic process. Cellular tumor antigen p53 is clinically significant because abnormalities in its function have been thought to be involved with diseases like Li-Fraumeni syndrome (LFS), lung cancer (LNCR) and bone marrow failure syndrome 5 (BMFS5). Bone marrow failure syndrome 5, an autosomal dominant inheritancedisorder characterized by delayed skeletal maturation, seizures and global developmental delay, has especially been of interest to scientists.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of p53 antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
FAQ
How can I lyse my cells without lysing the nuclear membrane?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?