Purified Mouse Anti-human/rat Cyclin D1 Antibody *CD1.1, monoclonal*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics, Immunoprecipitation
Other names | Clone CD1.1 | Host mouse | Reactivity human; rat | Application FC; IP; WB; IHC(P); IHC(F); ICC; ELISA |
G1/S-specific cyclin-D1 is a 34 kDa protein that can be expressed in the intracellular, host cell nucleus and cytosol of cells. It is sometimes called BCL-1 oncogene, PRAD1 oncogene and B-cell lymphoma 1 protein. In humans, G1/S-specific cyclin-D1 binds to histone deacetylase, enzyme and protein kinase. It has been closely linked to critical functions like cyclin-dependent protein serine/threonine kinase regulator, protein kinase and transcription corepressor activity. Sequencing of G1/S-specific cyclin-D1 has exemplified it contains a primary structural unit, the cyclin N-terminal domain. G1/S-specific cyclin-D1 plays an important role in organismal processes, namely, transcription initiation from RNA polymerase II promoter, mitotic cell cycle phase transition and response to organonitrogen compound. It suppresses transcription by RNA polymerase II, epithelial cell differentiation and cell cycle arrest while also upregulates mammary gland epithelial cell proliferation, G2/M transition of mitotic cell cycle and protein phosphorylation. G1/S-specific cyclin-D1 is the subject of intensive examination because of the fact that it is a component of the cytokine-mediated signaling pathway and Wnt signaling pathway. Mutations and abnormalities in G1/S-specific cyclin-D1 have been closely linked to a number of diseases, for instance, multiple myeloma (MM). Multiple myeloma, a disorder characterized by paraproteinemia and abnormality of blood and blood-forming tissues, has in particular been of interest to researchers.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of Cyclin D1 antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
FAQ
How can I lyse my cells without lysing the nuclear membrane?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?