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Purified Rabbit Anti-human ZAP70 Antibody
PAb (430), monoclonal
Tyrosine-protein kinase ZAP-70 (sometimes referred to as Syk-related tyrosine kinase) is a protein with a molecular weight of 70 kDa, found in the cell-cell junction, cytoplasm and T cell receptor complex of cells. In humans, tyrosine-protein kinase ZAP-70 plays an important role in organismal processes, namely, adaptive immune response, protein phosphorylation and T cell differentiation. It has been closely linked to key functions like non-membrane spanning protein tyrosine kinase. Sequencing of tyrosine-protein kinase ZAP-70 has supported it contains 3 types of conserved structural units: SH2 1, SH2 2 and protein kinase domain. Tyrosine-protein kinase ZAP-70 takes part in processes such as cell population proliferation. It recognizes phosphotyrosine residue, ATP and signaling receptor. Tyrosine-protein kinase ZAP-70 acts to positively regulate calcium-mediated signaling, α-beta T cell differentiation and α-beta T cell proliferation. It is the subject of intensive research in part because it is involved with the T cell receptor signaling pathway and transmembrane receptor protein tyrosine kinase signaling pathway. Mutations and abnormalities in tyrosine-protein kinase ZAP-70 have been thought to be involved with a number of diseases, in particular, immunodeficiency 48 (IMD48) and autoimmune disease, multisystem, infantile-onset, 2 (ADMIO2). Immunodeficiency 48, an autosomal recessive inheritancedisorder characterized by eczema, recurrent candida infections and pneumonia, has especially been of interest to researchers.
| Catalog | Size | Price | Quantity |
|---|---|---|---|
| V1032455 | 0.1 mg | Price |
Antibody properties
| Clone | PAb (430) |
| Host | Rabbit |
| Reactivity | Human |
| Application | Western Blot |
Storage, safety and handling
| Intended use | Research Use Only (RUO) |
Contact us
| Telephone | |
| Fax | |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Technical Support | Contact us |
| Request quotation | Request |
| Purchase order | Send to sales@aatbio.com |
| Shipping | Standard overnight for United States, inquire for international |
Page updated on April 1, 2026