Purified Rabbit Anti-human ZAP70 Antibody *PAb (430), monoclonal*
Ordering information
Price | |
Catalog Number | |
Unit Size | |
Quantity |
Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics
Other names | Clone PAb (430) | Host rabbit | Reactivity human | Application WB |
Tyrosine-protein kinase ZAP-70 (sometimes referred to as Syk-related tyrosine kinase) is a protein with a molecular weight of 70 kDa, found in the cell-cell junction, cytoplasm and T cell receptor complex of cells. In humans, tyrosine-protein kinase ZAP-70 plays an important role in organismal processes, namely, adaptive immune response, protein phosphorylation and T cell differentiation. It has been closely linked to key functions like non-membrane spanning protein tyrosine kinase. Sequencing of tyrosine-protein kinase ZAP-70 has supported it contains 3 types of conserved structural units: SH2 1, SH2 2 and protein kinase domain. Tyrosine-protein kinase ZAP-70 takes part in processes such as cell population proliferation. It recognizes phosphotyrosine residue, ATP and signaling receptor. Tyrosine-protein kinase ZAP-70 acts to positively regulate calcium-mediated signaling, α-beta T cell differentiation and α-beta T cell proliferation. It is the subject of intensive research in part because it is involved with the T cell receptor signaling pathway and transmembrane receptor protein tyrosine kinase signaling pathway. Mutations and abnormalities in tyrosine-protein kinase ZAP-70 have been thought to be involved with a number of diseases, in particular, immunodeficiency 48 (IMD48) and autoimmune disease, multisystem, infantile-onset, 2 (ADMIO2). Immunodeficiency 48, an autosomal recessive inheritancedisorder characterized by eczema, recurrent candida infections and pneumonia, has especially been of interest to researchers.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of ZAP70 antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
FAQ
How can I lyse my cells without lysing the nuclear membrane?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?