Name: Texas Red TCO *Single isomer*
Brand: AAT Bioquest
SKU: 899
Price: 221 USD
Availability: InStock

Texas Red TCO

Single isomer

The tetrazine-trans-cyclooctene (TCO) ligation constitutes a non-toxic biomolecule labeling method of unparalleled speed. A tetrazine-functionalized molecule reacts with a TCO-functionalized molecule, forming a stable conjugate via a dihydropyrazine moiety. This inverse electron demand cycloaddition reaction has gained popularity due to the potential for extremely fast cycloaddition kinetics with TCO as the dienophile. AAT Bioquest offers a group of tetrazine- and TCO-containing dyes for exploring various biological systems that can use this powerful click reaction. Texas Red-TCO can be readily used to label tetrazine-modified biological molecules for fluorescence imaging and other fluorescence-based biochemical analysis. It is widely used for labeling tetrazine-modified peptides, proteins and oligos etc.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
899	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Texas Red TCO *Single isomer* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	122.698 µL	613.489 µL	1.227 mL	6.135 mL	12.27 mL
5 mM	24.54 µL	122.698 µL	245.396 µL	1.227 mL	2.454 mL
10 mM	12.27 µL	61.349 µL	122.698 µL	613.489 µL	1.227 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	815.01 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

Conditionally Controlling Human TLR2 Activity via Trans-Cyclooctene Caged Ligands.

Authors:

van de Graaff, Michel J and Oosenbrug, Timo and Marqvorsen, Mikkel H S and Nascimento, Clarissa R and de Geus, Mark A R and Manoury, Bénédicte and Ressing, Maaike E and van Kasteren, Sander I

Journal:

Bioconjugate chemistry (2020): 1685-1692

Titanium coating with mussel inspired polymer and bio-orthogonal chemistry enhances antimicrobial activity against Staphylococcus aureus.

Authors:

Czuban, Magdalena and Kulka, Michaël W and Wang, Lei and Koliszak, Anna and Achazi, Katharina and Schlaich, Christoph and Donskyi, Ievgen S and Di Luca, Mariagrazia and Mejia Oneto, Jose M and Royzen, Maksim and Haag, Rainer and Trampuz, Andrej

Journal:

Materials science & engineering. C, Materials for biological applications (2020): 111109

Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies.

Authors:

Nazarova, Lidia and Rafidi, Hanine and Mandikian, Danielle and Ferl, Gregory Z and Koerber, James T and Davies, Christopher W and Ulufatu, Sheila and Ho, Jason and Lau, Jeffrey and Yu, Shang-Fan and Ernst, James and Sadowsky, Jack D and Boswell, C Andrew

Journal:

Molecular cancer therapeutics (2020): 1052-1058

Tetrazine Carbon Nanotubes for Pretargeted In Vivo "Click-to-Release" Bioorthogonal Tumour Imaging.

Authors:

Li, He and Conde, João and Guerreiro, Ana and Bernardes, Gonçalo J L

Journal:

Angewandte Chemie (International ed. in English) (2020)

A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry.

Authors:

Qiu, Lin and Tan, Hui and Lin, Qingyu and Si, Zhan and Mao, Wujian and Wang, Tingting and Fu, Zhequan and Cheng, Dengfeng and Shi, Hongcheng

Journal:

Molecular imaging and biology (2020): 842-853

Physical properties

Molecular weight	815.01
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.23
Correction factor (280 nm)	0.36
Correction factor (565 nm)	0.4472
Extinction coefficient (cm ^-1 M ^-1)	116000 ¹
Excitation (nm)	586
Emission (nm)	603
Quantum yield	0.97 ¹ , 0.93 ²

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on November 23, 2025