Texas Red TCO *Single isomer*
Ordering information
| Price | |
| Catalog Number | |
| Unit Size | |
| Quantity |
Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 815.01 |
| Solvent | DMSO |
Spectral properties
| Correction Factor (260 nm) | 0.23 |
| Correction Factor (280 nm) | 0.36 |
| Correction Factor (565 nm) | 0.4472 |
| Extinction coefficient (cm -1 M -1) | 1160001 |
| Excitation (nm) | 586 |
| Emission (nm) | 603 |
| Quantum yield | 0.971, 0.932 |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
| UNSPSC | 12171501 |
Direct upgrades
| iFluor® 594 TCO |
Related products
| Overview |  SDSProtocol |
Upgrade: iFluor® 594 TCO
Molecular weight 815.01 | Correction Factor (260 nm) 0.23 | Correction Factor (280 nm) 0.36 | Correction Factor (565 nm) 0.4472 | Extinction coefficient (cm -1 M -1) 1160001 | Excitation (nm) 586 | Emission (nm) 603 | Quantum yield 0.971, 0.932 |
The tetrazine-trans-cyclooctene (TCO) ligation constitutes a non-toxic biomolecule labeling method of unparalleled speed. A tetrazine-functionalized molecule reacts with a TCO-functionalized molecule, forming a stable conjugate via a dihydropyrazine moiety. This inverse electron demand cycloaddition reaction has gained popularity due to the potential for extremely fast cycloaddition kinetics with TCO as the dienophile. AAT Bioquest offers a group of tetrazine- and TCO-containing dyes for exploring various biological systems that can use this powerful click reaction. Texas Red-TCO can be readily used to label tetrazine-modified biological molecules for fluorescence imaging and other fluorescence-based biochemical analysis. It is widely used for labeling tetrazine-modified peptides, proteins and oligos etc.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Texas Red TCO *Single isomer* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 122.698 µL | 613.489 µL | 1.227 mL | 6.135 mL | 12.27 mL |
| 5 mM | 24.54 µL | 122.698 µL | 245.396 µL | 1.227 mL | 2.454 mL |
| 10 mM | 12.27 µL | 61.349 µL | 122.698 µL | 613.489 µL | 1.227 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Spectrum
Open in Advanced Spectrum Viewer
Spectral properties
| Correction Factor (260 nm) | 0.23 |
| Correction Factor (280 nm) | 0.36 |
| Correction Factor (565 nm) | 0.4472 |
| Extinction coefficient (cm -1 M -1) | 1160001 |
| Excitation (nm) | 586 |
| Emission (nm) | 603 |
| Quantum yield | 0.971, 0.932 |
Product Family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) | Quantum yield | Correction Factor (260 nm) | Correction Factor (280 nm) | Correction Factor (565 nm) |
| Texas Red® hydrazide *Single Isomer* | 586 | 603 | 1160001 | 0.971, 0.932 | 0.23 | 0.36 | 0.4472 |
| Texas Red® cadaverine *Single Isomer* | 586 | 603 | 1160001 | 0.971, 0.932 | 0.23 | 0.36 | 0.4472 |
| Texas Red® maleimide *Single Isomer* | 586 | 603 | 1160001 | 0.971, 0.932 | 0.23 | 0.36 | 0.4472 |
| Texas Red® azide *Single Isomer* | 586 | 603 | 1160001 | 0.971, 0.932 | 0.23 | 0.36 | 0.4472 |
| Texas Red® alkyne *Single Isomer* | 586 | 603 | 1160001 | 0.971, 0.932 | 0.23 | 0.36 | 0.4472 |
| Texas Red-DHPE *CAS 187099-99-6* | 586 | 603 | 1160001 | 0.971, 0.932 | 0.23 | 0.36 | 0.4472 |
Images
Figure 1. Chemical structure for Texas Red TCO *Single isomer*.
References
View all 50 references: Citation Explorer
Conditionally Controlling Human TLR2 Activity via Trans-Cyclooctene Caged Ligands.
Authors: van de Graaff, Michel J and Oosenbrug, Timo and Marqvorsen, Mikkel H S and Nascimento, Clarissa R and de Geus, Mark A R and Manoury, Bénédicte and Ressing, Maaike E and van Kasteren, Sander I
Journal: Bioconjugate chemistry (2020): 1685-1692
Authors: van de Graaff, Michel J and Oosenbrug, Timo and Marqvorsen, Mikkel H S and Nascimento, Clarissa R and de Geus, Mark A R and Manoury, Bénédicte and Ressing, Maaike E and van Kasteren, Sander I
Journal: Bioconjugate chemistry (2020): 1685-1692
Cellular Delivery of Bioorthogonal Pretargeting Therapeutics in PSMA-Positive Prostate Cancer.
Authors: Hapuarachchige, Sudath and Huang, Colin T and Donnelly, Madeline C and Bařinka, Cyril and Lupold, Shawn E and Pomper, Martin G and Artemov, Dmitri
Journal: Molecular pharmaceutics (2020): 98-108
Authors: Hapuarachchige, Sudath and Huang, Colin T and Donnelly, Madeline C and Bařinka, Cyril and Lupold, Shawn E and Pomper, Martin G and Artemov, Dmitri
Journal: Molecular pharmaceutics (2020): 98-108
Ultra-fast Cycling for Multiplexed Cellular Fluorescence Imaging.
Authors: Ko, Jina and Oh, Juhyun and Ahmed, Maaz S and Carlson, Jonathan C T and Weissleder, Ralph
Journal: Angewandte Chemie (International ed. in English) (2020): 6839-6846
Authors: Ko, Jina and Oh, Juhyun and Ahmed, Maaz S and Carlson, Jonathan C T and Weissleder, Ralph
Journal: Angewandte Chemie (International ed. in English) (2020): 6839-6846
Pre-targeted Imaging of Protease Activity through In Situ Assembly of Nanoparticles.
Authors: Chen, Zixin and Chen, Min and Zhou, Kaixiang and Rao, Jianghong
Journal: Angewandte Chemie (International ed. in English) (2020): 7864-7870
Authors: Chen, Zixin and Chen, Min and Zhou, Kaixiang and Rao, Jianghong
Journal: Angewandte Chemie (International ed. in English) (2020): 7864-7870
Antibody Pretargeting Based on Bioorthogonal Click Chemistry for Cancer Imaging and Targeted Radionuclide Therapy.
Authors: Rondon, Aurélie and Degoul, Françoise
Journal: Bioconjugate chemistry (2020): 159-173
Authors: Rondon, Aurélie and Degoul, Françoise
Journal: Bioconjugate chemistry (2020): 159-173
Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics.
Authors: de Geus, Mark A R and Maurits, Elmer and Sarris, Alexi J C and Hansen, Thomas and Kloet, Max S and Kamphorst, Kiki and Ten Hoeve, Wolter and Robillard, Marc S and Pannwitz, Andrea and Bonnet, Sylvestre A and Codée, Jeroen D C and Filippov, Dmitri V and Overkleeft, Herman S and van Kasteren, Sander I
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
Authors: de Geus, Mark A R and Maurits, Elmer and Sarris, Alexi J C and Hansen, Thomas and Kloet, Max S and Kamphorst, Kiki and Ten Hoeve, Wolter and Robillard, Marc S and Pannwitz, Andrea and Bonnet, Sylvestre A and Codée, Jeroen D C and Filippov, Dmitri V and Overkleeft, Herman S and van Kasteren, Sander I
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
Hybrid Imaging Agents for Pretargeting Applications Based on Fusarinine C-Proof of Concept.
Authors: Summer, Dominik and Petrik, Milos and Mayr, Sonja and Hermann, Martin and Kaeopookum, Piriya and Pfister, Joachim and Klingler, Maximilian and Rangger, Christine and Haas, Hubertus and Decristoforo, Clemens
Journal: Molecules (Basel, Switzerland) (2020)
Authors: Summer, Dominik and Petrik, Milos and Mayr, Sonja and Hermann, Martin and Kaeopookum, Piriya and Pfister, Joachim and Klingler, Maximilian and Rangger, Christine and Haas, Hubertus and Decristoforo, Clemens
Journal: Molecules (Basel, Switzerland) (2020)
Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes.
Authors: Cobley, James and Noble, Anna and Bessell, Rachel and Guille, Matthew and Husi, Holger
Journal: Antioxidants (Basel, Switzerland) (2020)
Authors: Cobley, James and Noble, Anna and Bessell, Rachel and Guille, Matthew and Husi, Holger
Journal: Antioxidants (Basel, Switzerland) (2020)
Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure.
Authors: Li, Shuxin and Zhou, Jun and Huang, YiHui and Roy, Joyita and Zhou, Ning and Yum, Kyungsuk and Sun, Xiankai and Tang, Liping
Journal: Acta biomaterialia (2020): 95-104
Authors: Li, Shuxin and Zhou, Jun and Huang, YiHui and Roy, Joyita and Zhou, Ning and Yum, Kyungsuk and Sun, Xiankai and Tang, Liping
Journal: Acta biomaterialia (2020): 95-104
A Systematic Study of Coumarin-Tetrazine Light-Up Probes for Bioorthogonal Fluorescence Imaging.
Authors: Galeta, Juraj and Dzijak, Rastislav and Obořil, Jan and Dračínský, Martin and Vrabel, Milan
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
Authors: Galeta, Juraj and Dzijak, Rastislav and Obořil, Jan and Dračínský, Martin and Vrabel, Milan
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)