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XFD350 Anti-human CD11b Antibody
ICRF44
ICRF44 is an anti-human monoclonal antibody that forms an immune complex with the CD11b antigen. CD11b (also known as Mo1 or Mac-1) is a 165 - 170 kD transmembrane glycoprotein that is expressed on the surface of cells such as dendritic cells, macrophages, NK cells and T cells. In some organisms, CD11b is involved in the positive regulation of neuron death, is a promoter of hippocampal neuron apoptotic process and is a positive regulator of protein targeting to membrane. Furthermore, it has been thought to be involved with vital biological processes such as cell adhesion, specifically cell-cell adhesion via plasma-membrane adhesion molecules. CD11b is a member of vital cellular pathways, for example, the integrin-mediated signaling pathway, apoptotic signaling pathway and toll-like receptor 4 signaling pathway. From a research standpoint, it is of biological interest due to its association with essential macromolecules/ligands like iC3b, ICAM-1, Factor X and 2. CD11b is a very popular antibody target, with over 45000 publications in the last decade. CD11b is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, especially in the study of innate immunity and immunology. This antibody was purified through affinity chromatography and conjugated to XFD350 (ex/em = 343/441 nm). XFD350 is manufactured by AAT Bioquest, and it has a chemical structure similar to that of Alexa Fluor® 350 (Alexa Fluor® is the trademark of Thermo Fisher). It is compatible with the 355 nm laser and 447/60 nm bandpass filter (for example, as in the Bio-Rad ZE5 Cell Analyzer).
| Catalog | Size | Price | Quantity |
|---|---|---|---|
| 10112140 | 100 tests | Price | |
| 10112141 | 500 tests | Price |
Antibody properties
| Other names | CR3, Mac-1, Mo1, ITGAM, Integrin alpha-M |
| Clone | ICRF44 |
| Host | Mouse |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Application | Flow Cytometry (FACS), Fluorescence Imaging |
Spectral properties
| Correction factor (260 nm) | 0.25 |
| Correction factor (280 nm) | 0.19 |
| Extinction coefficient (cm -1 M -1) | 19000 |
| Excitation (nm) | 343 |
| Emission (nm) | 441 |
Usage and storage
| Intended use | Research Use Only (RUO) |
Contact us
| Telephone | |
| Fax | |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Technical Support | Contact us |
| Request quotation | Request |
| Purchase order | Send to sales@aatbio.com |
| Shipping | Standard overnight for United States, inquire for international |
Page updated on July 31, 2026