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AAT Bioquest

Can next-generation sequencing (NGS) be used for virus genomes?

Posted May 9, 2020


Answer

Although more difficult to sequence due to the low abundance of viral RNA compared to that of a host, it is entirely possible to use next-generation sequencing for viral genomes.

Additional resources

Marston, D. A., McElhinney, L. M., Ellis, R. J., Horton, D. L., Wise, E. L., Leech, S. L., ... & Fooks, A. R. (2013). Next generation sequencing of viral RNA genomes. BMC genomics, 14(1), 444.