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Do you have any dual-fluorescence nucleic acid stains that interact with both DNA and RNA?

Posted March 8, 2018


Answer

Yes, both Hydroxystilbamidine and Acridine orange interact with DNA and RNA.

Hydroxystilbamidine, trade name FluoroGold, is a fluorescent dye that emits distinctly different fluorescence emission profiles when bound to DNA (Ex/Em = 360/590nm) and RNA (Ex/Em = 360/540 nm).

Acridine orange is cell-permeable cationic dye that interacts with DNA (Ex/Em = 502/525 nm) and RNA (Ex/Em = 460/650 nm) by intercalation or electrostatic attractions.

Additional resources

Hydroxystilbamidine Product Page

Acridine Orange Product Page