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Is Hoechst cell permeable?

Posted May 6, 2021


Answer

Yes, Hoechst is cell permeable. Both, Hoechst 33258 and Hoechst 33342 are cell permeable, however Hoechst 33342 is considerably more cell permeable because of the addition of a lipophilic ethyl group. Hoechst 33342 is usually the preferred choice for staining living cells.

Additional resources

SiR-Hoechst is a far-red DNA stain for live-cell nanoscopy

Hoechst 33342 *Ultrapure Grade*

Hoechst 33258 *CAS 23491-45-4*