AAT Bioquest

What do lysosomes have to do with the Golgi apparatus?

Posted April 2, 2021


The digestive enzymes lysosomes use to degrade extracellular materials is first processed and packaged into transport vesicles by the Golgi apparatus. The Golgi is the cells main protein processing and packaging center. It receives newly synthesized proteins from the rough ER, biochemically modifies them, and then packages them into vesicles and ships them to a targeted destination. While some of these transport vesicles are shipped to the cell surface for secretion, other transport vesicles remain within the cell and fuse with endosomes to form lysosomes. 

Additional resources

Induced oligomerization targets Golgi proteins for degradation in lysosomes

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