The best way to make own lysis buffer is to optimize the ingredient concentration to best suit the requirement. 

The best buffer for maintaining the native form of a protein is a non-denaturing buffer. It consists of: 

• 1% Nonidet P-40 (NP-40) or Triton X-100
• 150 mM NaCl
• 50mM Tris-HCl (pH 8)
• 2mM EDTA (Optional)
• Proteinase Inhibitor (Phenylmethylsulfonyl fluoride and/or dithiothreitol) 1mM

The best buffer for obtaining denatured protein is SDS lysis buffer. It consists of:

• 2% SDS
• 50mM Tris-HCl (pH 8)
• 10mM EDTA
• 10% Glycerol
• Proteinase Inhibitor (Phenylmethylsulfonyl fluoride and/or dithiothreitol) 1mM

For obtaining sub-cellular proteins (mitochondrial or nuclear proteins), the best buffer would be radioimmunoprecipitation assay (RIPA) buffer. It consists of

• 150 mM NaCl
• 1% NP-40 or Triton X-100
• 50mM Tris-HCl (pH 8.0)
• 0.1% SDS
• 0.5% sodium deoxycholate
• Proteinase Inhibitor (Phenylmethylsulfonyl fluoride and/or dithiothreitol) 1mM

Possible variations in the buffer constituents include varying detergent concentration, increasing salt concentration, or changing the detergents (such as saponin, CHAPS, digitonin, etc.,) in the protocol