AAT Bioquest

What is the endosome system?

Posted May 18, 2020


An endosome is a membrane-bound compartment inside a eukaryotic cell. It is originated from the trans Golgi network and is an organelle of the endocytic membrane transport pathway, where various cargo molecules required for normal cellular function are internalized, recycled and modulated. Endosomes can be classified as early, sorting, or late depending on their stage post internalization, which mature into lysosomes at the end of the endocytic pathway. Their major function is to provide an environment for material to be sorted before it reaches the degradative lysosome.

Additional resources

Intracellular pH

Hu, Y.-B., Dammer, E. B., Ren, R.-J., & Wang, G. (2015). The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration. Translational Neurodegeneration, 4(1). doi:10.1186/s40035-015-0041-1

Cell Structures and Organelles