What is the essential difference between apoptosis and necrosis?
Posted May 18, 2020
Apoptosis and necrosis are two mechanisms involved in the cell death. The main difference between them is that apoptosis is a naturally occurring physiological process where the cell actively destroys itself in a highly regulated manner; whereas necrosis is an accidental cell death caused by the uncontrolled external factors, which is an unregulated, random pathological process.
Fink, S. L., & Cookson, B. T. (2005). Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells. Infection and Immunity, 73(4), 1907–1916. doi:10.1128/iai.73.4.1907-1916.2005