AAT Bioquest

What is tissue on a chip?

Posted January 6, 2022


Tissue on a chip is a type of engineered microsystem that represents units of human organs such as the heart, lungs, and liver. A tissue on a chip microsystem models both structure and function of the organ. The chip is lined by living cells and contains certain features that are designed to mimic the complex biological functions of specific organs.

This innovative technology increases the reliability of toxicology and efficacy screening in drug development, providing researchers with insights that would allow them to more accurately predict the effectiveness of different drugs on humans. 

Ultimately, tissue chips provide faster and improved drug safety testing across the entire spectrum of drug development, accelerating the availability of new treatments for patients.

Additional resources

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

HHBS [Hanks' Buffer with 20 mM Hepes]

Cell Cytotoxicity