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What markers can I use for macrophages?
Posted May 9, 2020
Antibodies and Proteomics BioconjugationAntibody and Protein LabelingCluster of Differentiation (CD Antibodies)IHCImmunohistochemistry (IHC)
Answer
Some commonly used markers for macrophages are CD11b, CD68, and F4/80. In addition, other markers can be used to distinguish M1 and M2 macrophages: CD80, CD86, iNOS, and MHC-II can be used to identify M1 macrophages, which are involved in pro-inflammatory and immune responses; CD163, CD206, and CD209 can be used to identify M2 macrophages, which are involved in cell proliferation and tissue repair.
Additional resources
Kong, D., Zhou, C., Guo, H., Wang, W., Qiu, J., Liu, X., ... & Wang, Y. (2018). Praziquantel targets M1 macrophages and ameliorates splenomegaly in chronic schistosomiasis. Antimicrobial agents and chemotherapy, 62(1), e00005-17. Yao, Y., Xu, X. H., & Jin, L. (2019). Macrophage polarization in physiological and pathological pregnancy. Frontiers in immunology, 10, 792. Orecchioni, M., Ghosheh, Y., Akula Bala, P., & Ley, K. (2019). Macrophage polarization: different gene signatures in M1 (LPS+) versus classically and M2 (LPS-) versus alternatively activated macrophages. Frontiers in immunology, 10, 1084. iFluor™ A7 Anti-human CD11b Antibody *ICRF44*Cluster of Differentiation (CD Antibodies)