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What markers can I use for investigating microglial activation in flow cytometry?
Posted May 9, 2020
Antibodies and Proteomics BioconjugationAntibody and Protein LabelingCluster of Differentiation (CD Antibodies)Flow Cytometry ReagentsIHCImmunohistochemistry (IHC)flow cytometry
Answer
Some markers that can be used to studying microglial activation include CD40, CD45, CD68, CD86, and MHC-II.
Additional resources
Hopperton, K. E., Mohammad, D., Trépanier, M. O., Giuliano, V., & Bazinet, R. P. (2018). Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review. Molecular psychiatry, 23(2), 177-198. Ponomarev, E. D., Shriver, L. P., & Dittel, B. N. (2006). CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation. The Journal of Immunology, 176(3), 1402-1410. Cluster of Differentiation (CD Antibodies)
iFluor® A7 Anti-human CD45 AntibodyiFluor® A7 Anti-human CD40 Antibody *G28.5*