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What part of the DNA strand does Hoechst bind to?
Posted May 6, 2021
NucleusDNA and RNAPhysiological Probes
Answer

Hoechst binds to the minor groove of double-stranded DNA with a marked preference for AT (adenine-thymine)-rich sequences.

Additional resources
Interaction of Hoechst 33258 with the minor groove of the A + T-rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopyHoechst 33342 *Ultrapure Grade*oechst 33258 *CAS 23491-45-4*

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