Is beta galactosidase hydrophobic?

Yes, studies show that beta galactosidase sequences are predominantly hydrophobic. Its hydrophobic nature is due to the abundance of non-polar amino acid residues in its sequence. The glucose subsite of beta galactosidase is hydrophobic. Beta galactosides, which contain sugar moiety, bind efficiently to the enzyme when they have hydrophobic groups instead of glucose. As the beta galactosidase enzyme begins to break down the beta galactoside molecule, there is a significant increase in the affinity for d-glucose once the glycosidic bond is broken.