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AAT Bioquest

What are the differences between Alpha and Beta Galactosidase?

Posted December 7, 2023


Answer

Basis of differentiation

Alpha Galactosidase

Beta Galactosidase

Definition

Is an enzyme that breaks down substrates that contain alpha galactosidase residues such as glycoproteins 

Is an enzyme that breaks down beta galactosidase into monosaccharides

Molecular weight 

101 Kd

465 kDa

Substrates

Glycoproteins, glycolipids, polysaccharides,

Lactose, ganglioside GM1, lactosylceramides

Gene encoded

GLA gene

GLA gene

Disease associated with defects

Fabry disease

GM1 gangliosidosis, Morquio B disease  

Additional resources

Enhancement of alpha- and beta-galactosidase activity in Lactobacillus reuteri by different metal ions

Enzymes

Amplite® Colorimetric Beta-Galactosidase Assay Kit