One advantage is that fluorescent proteins can be genetically encoded and fused to proteins of interest, allowing for specific labeling of target molecules within cells. There is a wide variety of fluorescent proteins available with different spectral properties, allowing for flexibility in designing FRET pairs designed to specific experimental needs. Fluorescent proteins are also compatible with live-cell imaging techniques, making them suitable for studying cellular processes in real time. Another advantage is that fluorescent proteins are relatively stable, allowing them to be used in long-term imaging studies.