What are the advantages of indirect detection methods in immunohistochemistry (IHC)?

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This process provides a stronger signal because it uses multiple secondary antibodies, which bind to each primary antibody. 
The type of label or detection techniques used can be changed easily for new assays by changing secondary antibodies. 
Researchers can choose from a wider variety of labels. 
Making all primary antibodies in the same species can save labeling time and total cost. 
The use of biotinylated secondary antibodies amplifies sensitivity and signal even further while also allowing for greater flexibility.

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