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AAT Bioquest

What are the advantages of the yeast protein expression system?

Posted August 5, 2023


Answer

Yeast protein expression systems are faster, more convenient, and less expensive to grow than mammalian systems. They also provide a high level of protein expression (10-100 fold) as compared to E. coli. These systems also allow for the synthesis of both complex and multi-subunit proteins. Additionally, protein can be expressed as a secretory protein, which assists in the processing and purification of the gene product. Another advantage is that it is capable of post-translational protein modification and processing. It also provides high-density fermentation, which is suitable for industrial use. 

Additional resources

Yeast Expression Systems: Overview and Recent Advances

Antibodies and Proteomics