What are the advantages of whole genome bisulfite sequencing (WGBS)?

WGBS provides information on DNA methylation status across the entire genome, allowing for the detection of methylation patterns at single-base resolution. It provides detailed information about how genes are regulated during cell-fate commitment, gene regulation, and reprogramming processes. It also helps identify new epigenetic markers and potential targets for diseases. WGBS can detect even subtle changes in DNA methylation levels, making it suitable for studying epigenetic modifications.