There are several benefits of using agarose beads for immunoprecipitation experiments. Two key benefits are they offer high capacity and yield.
Agarose resin beads have a sponge-like structure with a large surface area, providing a high binding capacity for antibodies. In contrast, magnetic beads, while smaller and less porous, have a lower binding capacity.
Additionally, agarose beads can be manipulated with simple equipment like centrifuges or filtration systems, making them accessible for a wide range of labs. They are also more cost-effective in the short term compared to magnetic beads.