What are the common types of alternative splicing?
Posted July 22, 2022
There are five different types of alternative splicing: exon skipping, constitutive splicing, mutually exclusive splicing , alternative 3’ or 5’ splice site, and intron retention.
- Exon skipping is when an exon is spliced out of the primary RNA strand or kept; this is the most common type of alternative splicing.
- Constitutive splicing is the process of removing introns from pre-mRNA and sticking the exons together to form a mature mRNA.
- Mutually exclusive splicing is a type of splicing in which only one of two or more potential exons is spliced into the mature mRNA.
- The alternative 3’ splice acceptor site is used to change the 5’ downstream exon. The alternative 5’ splice donor site is used to change the 3’ upstream exon.
- Intron retention is an alternative splicing mode whereby introns are spliced out as an intron or retained in mature mRNAs.
Mechanism of alternative splicing and its regulation
Cell Navigator® Live Cell RNA Imaging Kit *Green Fluorescence*