What are the differences between autophagy and necroptosis?
Posted April 10, 2024
Basis of differentiation |
Autophagy |
Necroptosis |
Definition |
Is the body’s cellular recycling system in which the cell disassembles defective or non-functional parts, repurposing the salvageable fragments into new, usable cell parts while discarding the unnecessary pieces |
Is a caspase-independent, regulated form of necrosis in which cellular self-destruction is triggered when apoptosis (programmed cell death) is prevented |
Induction stimuli |
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Process |
May be physiological, pathophysiological, or active |
Mostly passive, always pathological |
Morphological changes |
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Molecular changes |
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Clearance |
Occurs by cannibalization of cells and recycling reusable contents for survival of the tissue |
Occurs by macrophages ingesting the necrotic cells accompanied by significant inflammation |